Effect of Carnitine on Uremic Cardiomyopathy

What Was Tested

In this not phased trial, researchers set out to test L-Carnitine.

Patients on chronic hemodialysis without obstructive coronary artery disease identified by coronary angiography were randomly divided into the two groups: carnitine group and control group.

Control group received the examination of BMIPP SPECT at the same time of the carnitine group.

It had two arms (groups): Carnitine group (experimental) and control group (no intervention).

No intervention.

The registry classes the interventions as drug.

More on the Plan

Circulating concentrations of total, free, and acyl L-carnitine were measured every three months in the carnitine group.

Clinical data including blood chemistry, blood pressure, or cardiac functions by echocardiography were obtained every 6 months in both groups.

The effects of chronic intravenous administration of L-carnitine on myocardial fatty acid metabolism and cardiac functions were investigated among this population.

Who Took Part

Enrollment: 60 actual participants took part.

It was open to people of any sex aged from 40 years up to 85 years.

Healthy volunteers were not accepted; participants needed the condition being studied.

Examples of who could join: Left ventricular hypertrophy evaluated by echocardiography).

The full record lists 3 inclusion and 2 exclusion criteria; among the exclusions: moderate or worse valvular heart disease,.

How the Study Was Run

It was run as a randomized, single-group and open-label study.

Because people in this L-Carnitine study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Being open-label, the L-Carnitine study did not mask who received what.

Everyone received the same intervention, so there was no separate comparison group inside the trial.

It started in 2013-08 with completion listed for 2014-10.

Its stated primary purpose is treatment.

What Was Measured

Primary outcome: changes in BMIPP summed scores of the SPECT imaging (time frame: one year: September 2013-October 2014 (up to 2 years)).

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of L-Carnitine in 60 people.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the L-Carnitine compound page, all human trials.