← Human Trials & Peer-Reviewed Studies
Role of Oxytocin in Telling and Detecting Lies
Plain-language guide to NCT02361177: early phase 1 randomized trial of Oxytocin. Who took part, design and what was measured.
Key Facts
- Registry ID
- NCT02361177
- Phase
- early phase 1
- Status
- withdrawn
- Start
- 2016-01
- Completion (planned or actual)
- 2016-04
- Participants
- n/a (actual)
- Design
- randomized, triple-blind, basic_science
- Conditions studied
- Dyssocial Behavior
- Results posted
- not yet
What This Study Did, in Plain Language
What Was Tested
The trial (early phase 1) is built around Oxytocin.
The investigators are interested in the impact of intranasal oxytocin in unethical behavior.
It had two arms (groups): oxytocin (experimental) and placebo (placebo comparator).
The registry classes the interventions as drug.
More on the Plan
The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior.
Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons.
It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion.
In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.
Who Took Part
It was open to men only aged from 18 years up to 30 years.
Healthy volunteers could join, not only people with the condition.
The full record lists 1 inclusion and 28 exclusion criteria; among the exclusions: \_\_\_\_\_ \_\_\_\_\_bp \> 130/85, hrt \> 95 (can be included at discretion of study physician/designee); \_\_\_\_\_history of seizures; \_\_\_\_\_neurological disorder.
How the Study Was Run
The set-up was randomized, parallel-group and triple-blind.
Because people in this Oxytocin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
The Oxytocin group and the comparison group ran side by side rather than switching.
As a double-blind Oxytocin study, the assignments were hidden from both participants and investigators until the end.
Those kept unaware of assignments: participant, investigator and outcomes assessor.
It started in 2016-01 with completion listed for 2016-04.
Its stated primary purpose is basic science.
What Was Measured
The main thing measured (primary outcome): Unethical behavior (time frame: 130 minutes).
What This Means in Plain Language
Put simply, this is a early phase 1, randomized trial of Oxytocin in people.
It was withdrawn before enrolling anyone; no results are posted to the registry yet, so nothing here describes outcomes.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: ClinicalTrials.gov record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.