Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function

What Was Tested

This registered not phased trial tested L-Carnitine.

A secondary aim of this project is to investigate the effects of carnitine with leucine supplementation, in comparison to carnitine supplementation alone, on muscle strength and body composition.

It had three arms (groups): L-carnitine Group (experimental), Leucine Group (experimental) and Control Group (experimental).

Group participated in the training protocol without any supplementation throughout 24 weeks.

The registry classes the interventions as dietary supplement and procedure.

More on the Plan

The study will be included volunteers - women between 60 - 72 years old (n=60).

The patients are randomly assigned to two experimental groups (n=20) and control group (n=20).

During the 24-weeks intervention period, Group A undergoes training procedure supplemented with the carnitine and leucine, whilst group B undergoes training procedure supplemented with leucine.

At the same time control group go through only training procedure.

Who Took Part

Enrollment: 60 actual participants took part.

It was open to women only aged from 60 years up to 72 years.

Healthy volunteers could join, not only people with the condition.

Examples of who could join: Aged-matched, no chronic disease, doctor's note about the lack of restrictions to perform resistance exercises.

The full record lists 1 inclusion and 1 exclusion criteria; among the exclusions: diabetes, liver, heart and renal diseases, gastric problems, as well as using the vitamin supplements.

How the Study Was Run

Design: randomized, parallel-group and triple-blind.

Because people in this L-Carnitine study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Groups ran in parallel: each of the participants stayed in one arm throughout.

As a double-blind L-Carnitine study, the assignments were hidden from both participants and investigators until the end.

Those kept unaware of assignments: participant, care provider and outcomes assessor.

It started in 2017-09-01 with completion listed for 2018-07-07.

It ran at 1 site in Poland.

Its stated primary purpose is prevention.

What Was Measured

Primary outcome: Volumetric changes in knee extensor muscle.

It also tracked 2 secondary outcomes, for example Changes in the strength of muscle knee extensor and Changes in Lean Body Mass.

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of L-Carnitine in 60 people.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the L-Carnitine compound page, all human trials.