Prenatal Aspirin and Postpartum Vascular Function

What Was Tested

This registered early phase 1 trial tested Endothelin-1.

Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.

It had 1 arm (groups): assessment of microvascular function (experimental).

The investigators use intradermal microdialysis to deliver acetylcholine, acetylcholine + L-NAME, endothelin-1, endothelin-1 + BQ-788, and endothelin-1 + BQ-123 to the cutaneous microvasculature.

The registry classes the interventions as drug.

Who Took Part

60 planned participants were the target.

It was open to women only aged from 18 years up to 50 years.

Healthy volunteers could join, not only people with the condition.

Examples of who could join: 18 years or older,. 12 weeks to 5 years postpartum. And one of the following:. Women who had a normal pregnancy and did not use low does aspirin (LDA) during pregnancy,. Women who had a normal pregnancy and used LDA during pregnancy,.

The full record lists 19 inclusion and 0 exclusion criteria.

How the Study Was Run

The set-up was single-group and open-label.

Being open-label, the Endothelin-1 study did not mask who received what.

Everyone received the same intervention, so there was no separate comparison group inside the trial.

It started in 2023-01-03 with completion listed for 2027-03-31.

It ran at 1 site in United States.

Its stated primary purpose is basic science.

What Was Measured

The main thing measured (primary outcome): microvascular endothelial function (time frame: at the study visit, an average of 4 hours). microvascular endothelin-1-mediated constriction (time frame: at the study visit, an average of 4 hours).

What This Means in Plain Language

Put simply, this is a early phase 1 trial of Endothelin-1 in 60 people.

It is still recruiting; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the Endothelin-1 compound page, all human trials.