Effect of rhBNP on CMD in Patients With STEMI After PPCI

What Was Tested

This registered not phased trial tested BNP (Nesiritide).

The target population of this interventional study was STEMI patients.

It had two arms (groups): Experimental Group 1 (experimental) and Control Gruop (no intervention).

The experimental group was given an intravenous infusion of the same amount of normal saline.

The registry classes the interventions as drug.

More on the Plan

Direct percutaneous coronary intervention is the preferred reperfusion strategy for acute ST-segment elevation myocardial infarction.

Prolonged ischemia leads to rapid depletion of intracellular ATP and tissue metabolic acidosis.

Who Took Part

Enrollment: 160 planned participants were the target.

It was open to people of any sex aged from 18 years up to 80 years.

Healthy volunteers were not accepted; participants needed the condition being studied.

Examples of who could join: PPCI within 24 hours of symptom onset. Target vessel QFR-MR\>250mm Hg\*s/m.

The full record lists 3 inclusion and 3 exclusion criteria; among the exclusions: postoperative timi grade 0-1.

How the Study Was Run

It was run as a randomized, parallel-group and triple-blind study.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The BNP (Nesiritide) group and the comparison group ran side by side rather than switching.

Blinding on both sides kept the participants and researchers unaware of who received BNP (Nesiritide).

Those kept unaware of assignments: participant, investigator and outcomes assessor.

It started in 2023-02-20 with completion listed for 2024-12-20.

Its stated primary purpose is treatment.

What Was Measured

Researchers chose this as the main measure: MVO/LV(%) (time frame: 3-14 days after PPCI).

It also tracked 7 secondary outcomes, for example LGE/LV(%), IMH, MVO/LV(%), LVEDV(ml), LVESV(ml) and Troponin (highest value).

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of BNP (Nesiritide) in 160 people.

Its status is unknown; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the BNP (Nesiritide) compound page, all human trials.