Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity

What Was Tested

In this not phased trial, researchers set out to test Oxytocin.

The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not.

It had two arms (groups): oxytocin (experimental) and placebo (experimental).

The registry classes the interventions as drug.

More on the Plan

The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and its underlying neural mechanisms and whether oxytocin has similar effects on them or not.

A double-blinded, placebo-controled, between-subject design is employed in this study.

In a randomized order, a total of 80 healthy males are instructed to self-administrated intranasal spray of oxytocin or placebo.

A modified inequity decision-making task starts 45 minutes after treatment with behavioral (fairness rating, preference rating and the choice rate of unequal option) and fMRI data being collected during this task.

Who Took Part

80 actual participants took part.

It was open to men only aged from 18 years up to 30 years.

Healthy volunteers could join, not only people with the condition.

Examples of who could join: Healthy subjects without past or current psychiatric or neurological disorders.

The full record lists 1 inclusion and 4 exclusion criteria; among the exclusions: history of head injury; pregnant,menstruating,taking oral contraceptives; medical or psychiatric illness.

How the Study Was Run

The set-up was randomized, parallel-group and double-blind.

The participants were allocated by chance, so the Oxytocin group and the comparison group should start out alike.

The Oxytocin group and the comparison group ran side by side rather than switching.

Blinding on both sides kept the participants and researchers unaware of who received Oxytocin.

Those kept unaware of assignments: participant and investigator.

It started in 2024-01-07 with completion listed for 2024-06-12.

It ran at 1 site in China.

Its stated primary purpose is basic science.

What Was Measured

Primary outcome: Behavioral index: fairness rating scores (time frame: 45-75 minutes after treatment administration). Behavioral index: preference rating scores (time frame: 45-75 minutes after treatment administration). Neural indices: fMRI-based measures of the outcome presentation stage (time frame: 45-75 minutes after treatment administration).

It also tracked 2 secondary outcomes, for example Behavioral index: choice rate of unequal option and Neural indices: fMRI-based measures of outcome and re-decision stages.

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of Oxytocin in 80 people.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the Oxytocin compound page, all human trials.