Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .

What Was Tested

This registered not phased trial tested Oxytocin.

Participants were randomized using computer-generated random numbers into 2 groups.

Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery.

It had two arms (groups): oxytocin before placental delivery (active comparator) and oxytocin after placental delivery (active comparator).

The registry classes the interventions as drug.

Who Took Part

Enrollment: 64 actual participants took part.

It was open to women only aged from 18 years up to 40 years.

Healthy volunteers were not accepted; participants needed the condition being studied.

Examples of who could join: Age 18 - 40 years. Singleton full term pregnancy. Candidate for elective cesarean delivery under spinal anaesthesia.

The full record lists 3 inclusion and 8 exclusion criteria; among the exclusions: women at high risk for intraoperative bleeding as those with placenta previa or other placental abnormalities; women with bleeding or coagulation disorders; medical disorder associating pregnancy as preeclampsia or diabetes.

How the Study Was Run

It was run as a randomized, parallel-group and double-blind study.

Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.

The Oxytocin group and the comparison group ran side by side rather than switching.

As a double-blind Oxytocin study, the assignments were hidden from both participants and investigators until the end.

Those kept unaware of assignments: participant and outcomes assessor.

It started in 2023-08-30 with completion listed for 2024-05-27.

It ran at 1 site in Egypt.

Its stated primary purpose is prevention.

What Was Measured

Researchers chose this as the main measure: Intraoperative blood loss (time frame: during cesarean delivery).

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of Oxytocin in 64 people.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the Oxytocin compound page, all human trials.