Bond Strength Evaluation

What Was Tested

This registered not phased trial tested DMSO (dimethyl sulfoxide, non-peptide solvent).

This study was evaluated the effect of dimethyl sulfoxide pretreatment on tensile bond strength and nanoleakage of resin composite bonded to aged dentin.

It had two arms (groups): DMSO (active comparator) and CHX (active comparator).

The registry classes the interventions as drug.

Who Took Part

The registry lists 30 actual participants took part.

It was open to people of any sex aged from 50 years up to 75 years.

Healthy volunteers were not accepted; participants needed the condition being studied.

Examples of who could join: Patients included in the study will be required to present at least one of non caries cervical lesion with sclerotic dentin without pulpal involvement. Age of patient: 50 - 75 years. Patients with non caries cervical lesion will be standardized by clinical performance (FDI world dental federation).

The full record lists 3 inclusion and 3 exclusion criteria; among the exclusions: teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling; developmental disorders and adjacent soft tissue lesions; patients with systemic illness will be excluded.

How the Study Was Run

The set-up was randomized, parallel-group and single-blind.

Random assignment meant chance, not the researchers, decided who got DMSO (dimethyl sulfoxide, non-peptide solvent) and who got the comparison, which limits bias.

Groups ran in parallel: each of the participants stayed in one arm throughout.

Only one side, usually the participants, was kept unaware of whether DMSO (dimethyl sulfoxide, non-peptide solvent) was given.

Those kept unaware of assignments: participant.

It started in 2025-11-01 with completion listed for 2026-05-01.

It ran at 1 site in Egypt.

Its stated primary purpose is prevention.

What Was Measured

Primary outcome: clinical assessment evaluation using the FDI world dental federation criteria (time frame: post operative 2 weeks).

It also tracked 1 secondary outcome, for example clinical assessment evaluation using the FDI world dental federation criteria.

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of DMSO (dimethyl sulfoxide, non-peptide solvent) in 30 people.

Its size is small, so on its own it can only give an early look.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.