Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigmentation

What Was Tested

This registered phase 2 trial tested Glutathione for hyperparathyroidism.

INTERVENTION: Patch test on forearm will be performed in all patients before starting treatment to check the sensitivity.

Site of burn in the enrolled patients will include either cheek or forehead and total area (cm2) on each of above mentioned sites will be divided into two equal halves; one for tranexamic acid mesotherapy (maximum 5cm2) and other for glutathione mesotherapy (maximum 5cm2).

Flip coin method will be used to decide which site and which half to be treated with tranexamic Acid or glutathione.

It had 1 arm (groups): fitzpatrick skin type3,4 patients of post burn facial hyperpigmentation will be included in this arm (experimental).

Facial hyperpigmentation lesion will be divided into 2 halves and one treatment will be administered on each half.

The registry classes the interventions as drug.

More on the Plan

This will be the first study on local and international level for measurement of post burn facial hyperpigmentation as to date there are no reliable objective methods for measuring skin hyperpigmentation quantitatively in this population of patients.

Their study, with availability of ideal population sample from one of the largest burn centre in the country, will surely add to scarce knowledge currently published in literature regarding the use of tranexamic acid and glutathione to overcome hyperpigmentation.

Mesotherapy Mesotherapy is a procedure in which multiple microinjections of tranexamic acid or glutathione will be given 1 cm apart for treating post burn facial hyperpigmentation.

Duration of Study Study will be completed within 6 months after approval of synopsis.

Who Took Part

60 planned participants were the target.

It was open to people of any sex aged from 18 years up to 65 years.

Healthy volunteers were not accepted; participants needed the condition being studied.

Examples of who could join: Patients with healed facial burns managed conservatively without skin grafting. From 6 month to 12 month post burn injury (patient enrollment to be done before scar maturation starts). Patients with Fitzpatrick skin types III to IV. Patients with mental capacity to give informed consent.

The full record lists 4 inclusion and 5 exclusion criteria; among the exclusions: history of de-pigmentation treatment, phototherapy; healed burn wounds with hypertrophic scar; history of bleeding or clotting disorders, renal disease, collagen vascular disease and other photodermatoses3.

How the Study Was Run

It was run as a single-group and open-label study.

Everyone knew when Glutathione was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Everyone received the same intervention, so there was no separate comparison group inside the trial.

It started in 2025-06-01 with completion listed for 2025-12-26.

It ran at 1 site in Pakistan.

Its stated primary purpose is treatment.

What This Means in Plain Language

Put simply, this is a phase 2 trial of Glutathione in 60 people with hyperparathyroidism.

Its status is active not recruiting; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the Glutathione compound page, Hyperparathyroidism research.