Impact of Dentin Pretreatment With Dimethyl Sulfoxide on Behavior of Resin Composite Restorations in Non-Carious Cervical Lesions

What Was Tested

The trial (not phased) is built around DMSO (dimethyl sulfoxide, non-peptide solvent).

The aim of this study to evaluate and compare the impact of dimethyl sulfoxide dentin surface pretreatment on the performance of composite restorations in non-cervical carious lesions.

It had two arms (groups): one (experimental) and one (experimental).

Participants in this group will receive resin composite restorations using etch-and-rinse adhesive system under conventional wet-bonding without DMSO solution treatment . after acid aching, the dentin will be maintained in a visibility moist condition . the assigned adhesive system and resin composite material will be applied and polymerized in accordance with the standardized clinical protocol.

The registry classes the interventions as other.

Who Took Part

30 actual participants took part.

It was open to people of any sex aged from 18 years up to 60 years.

Healthy volunteers could join, not only people with the condition.

Examples of who could join: The cervical cavity margin had to be equigingival or supragingival. Participants had to be willing and able to comply with the study protocol and attend all scheduled follow-up visits.

The full record lists 8 inclusion and 1 exclusion criteria.

How the Study Was Run

It was run as a randomized, crossover and double-blind study.

Random assignment meant chance, not the researchers, decided who got DMSO (dimethyl sulfoxide, non-peptide solvent) and who got the comparison, which limits bias.

Each person switched between DMSO (dimethyl sulfoxide, non-peptide solvent) and the comparison at some point, usually with a gap in between.

Blinding on both sides kept the participants and researchers unaware of who received DMSO (dimethyl sulfoxide, non-peptide solvent).

Those kept unaware of assignments: participant and investigator.

It started in 2023-12-15 with completion listed for 2025-12-15.

It ran at 1 site in Egypt.

Its stated primary purpose is treatment.

What Was Measured

Researchers chose this as the main measure: 1. FDI criteria score-aesthetic properties (A1 surface luster and surface texture; A2 Marginal staining; A3 color match), Functional (F1 Fracture/Retention; F2 marginal adaptation), biological (B1 caries at restoration margin) (time frame: Post-restoration baseline (2 weeks), 6, 12, 18, and 24 months). FDI criteria score (time frame: Post-restoration baseline (2 weeks), 6, 12, 18, and 24 months).

What This Means in Plain Language

Put simply, this is a not phased, randomized trial of DMSO (dimethyl sulfoxide, non-peptide solvent) in 30 people.

Its size is small, so on its own it can only give an early look.

The trial is marked completed; no results are posted to the registry yet, so nothing here describes outcomes.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.