Concomitant treatment with urodilatin (ularitide) does not improve renal function in patients with acute renal failure after major abdominal surgery--a randomized controlled trial.

What Was Tested

Researchers studied Dopamine and Furosemide in this randomized controlled trial publication.

The aim of the study was to investigate the effect of urodilatin on the peak value and course of serum creatinine in patients with acute renal insufficiency after major abdominal surgery and the necessity of apparatus-based renal replacement treatment.

Why It Was Studied

Acute renal failure after major abdominal surgery is a severe complication in critically ill patients in intensive care units (ICU).

Furthermore, the incidence and nature of adverse events under urodilatin was documented.

Who Took Part

According to the abstract, 12 patients were involved.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Dopamine study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Dopamine study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Dopamine, giving a reference point.

What Was Measured

PubMed files the paper under topics including Abdomen, Acute Kidney Injury, Atrial Natriuretic Factor, Critical Care, Diuretics, Dopamine and Furosemide.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Dopamine and Furosemide in 12 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1999 (Wiener klinische Wochenschrift), a journal based in Austria.

More context: all human trials.