Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans

Plain-language guide to PMID 10195374 (1999): placebo-controlled randomized controlled trial study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2 in 7 volunteers.

Key Facts

PMID: 10195374
Journal: Journal of endocrinological investigation
Year: 1999
Study type: Randomized Controlled Trial
Authors: Arvat E et al. (9 authors)
DOI: 10.1007/BF03350886

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial paper looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2.

Hexarelin (HEX) and GHRP-2 are two synthetic hexapeptides, superanalogs of GHRP-6, belonging to GH secretagogue (GHS) family.

GHS act via specific receptors at both the pituitary and the hypothalamic level to stimulate GH release both in animals and in humans.

Who Took Part

The study group was 7 volunteers.

PubMed indexes the participants as adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some volunteers received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.

What Was Measured

GHS act via specific receptors at both the pituitary and the hypothalamic level to stimulate GH release both in animals and in humans.

Basal GH, PRL, ACTH and cortisol levels in all testing sessions were similar.

Topics PubMed links to this paper include Adrenocorticotropic Hormone, Growth Substances, Human Growth Hormone, Hydrocortisone, Oligopeptides and Prolactin.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2 in 7 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1999 (Journal of endocrinological investigation), a journal based in Italy.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the GHRP-2 compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

GHRP-2: A synthetic growth hormone secretagogue that activates the ghrelin receptor and can increase appetite.

Hexarelin: A potent synthetic hexapeptide GH secretagogue, also studied for direct heart effects via the CD36 receptor.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.