Growth hormone binding protein correlates strongly with leptin and percentage body fat in GH-deficient adults, is increased by GH replacement but does not predict IGF-I response.

Plain-language guide to PMID 10207506 (1999): randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Key Facts

PMID: 10207506
Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Year: 1999
Study type: Randomized Controlled Trial
Authors: Florkowski CM et al. (6 authors)
DOI: 10.1054/ghir.1998.0084

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

This study aimed to examine the inter-relationship between GHBP, leptin and body fat, and to test the hypothesis that GHBP is modified by GH replacement in GH-deficient adults and predicts IGF-I response.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Plasma GHBP and leptin were measured at baseline and 2, 4, 8 and 12 weeks after each treatment.

How the Study Was Run

In design terms this was a randomized, placebo-controlled and crossover study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.

In the crossover set-up each of the participants took both Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison in turn, acting as their own control.

Whole body composition was measured at baseline by dual-energy X-ray absorptiometry (DEXA).

What Was Measured

Topics PubMed links to this paper include Absorptiometry, Photon, Adipose Tissue, Body Composition, Carrier Proteins, Hormone Replacement Therapy, Human Growth Hormone and Hypopituitarism.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 1999 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.