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The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin
Plain-language guide to PMID 10404825 (1999): double-blind randomized controlled trial study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and ACTH (Corticotropin) in 15 volunteers.
Key Facts
- PMID
- 10404825
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Korbonits M et al. (7 authors)
- DOI
- 10.1210/jcem.84.7.5811
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and ACTH (Corticotropin), published as a randomized controlled trial.
GH secretagogues (GHSs) act via specific receptors in the hypothalamus and the pituitary gland to release GH.
GHSs also stimulate the hypothalamo-pituitary-adrenal (HPA) axis via central mechanisms probably involving CRH or arginine vasopressin (AVP).
Who Took Part
The study group was 15 volunteers.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized and double-blind.
Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
Circulating ACTH, cortisol, GH and PRL concentrations were measured for 2 h after the injection of hexarelin, CRH, or desmopressin alone and the combination of hexarelin plus CRH or hexarelin plus desmopressin.
Symptoms during the tests were assessed by visual analog scales.
What Was Measured
The subject headings attached to it are Adrenal Glands, Adrenocorticotropic Hormone, Arginine Vasopressin, Corticotropin-Releasing Hormone, Deamino Arginine Vasopressin, Growth Substances and Human Growth Hormone.
What This Means in Plain Language
The paper is a randomized and double-blind study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and ACTH (Corticotropin) in 15 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1999 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the ACTH (Corticotropin) compound page, all human trials.
Our Notes on the Compounds
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
- Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library
- ACTH (Corticotropin) in the library
- CRH (Corticotropin-Releasing Hormone) in the library
- Vasopressin in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.