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Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans
Plain-language guide to PMID 10451909 (1999): double-blind randomized controlled trial study of GHRH (Growth Hormone-Releasing Hormone) in 11 men.
Key Facts
- PMID
- 10451909
- Journal
- Psychoneuroendocrinology
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Perras B et al. (5 authors)
- DOI
- 10.1016/s0306-4530(99)00027-x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at GHRH (Growth Hormone-Releasing Hormone).
Here the researchers examined effects of GHRH on endocrine function and sleep after intranasal administration, a method which based on previous studies appears to enable a direct effect of peptides on brain function.
A study was performed according to a double-blind cross-over design.
Who Took Part
The study group was 11 men.
The age groups tagged for this paper are adults, older adults and people over 80, men only.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Because people in this GHRH (Growth Hormone-Releasing Hormone) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind GHRH (Growth Hormone-Releasing Hormone) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with GHRH (Growth Hormone-Releasing Hormone) could be set against what happens without it.
In the crossover set-up each of the men took both GHRH (Growth Hormone-Releasing Hormone) and the comparison in turn, acting as their own control.
What Was Measured
Topics PubMed links to this paper include Aging, Circadian Rhythm, Growth Hormone-Releasing Hormone, Human Growth Hormone, Hydrocortisone, Hypothalamo-Hypophyseal System and Sleep Stages.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of GHRH (Growth Hormone-Releasing Hormone) in 11 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1999 (Psychoneuroendocrinology), a journal based in England.
More context: the GHRH (Growth Hormone-Releasing Hormone) compound page, all human trials.
Our Notes on the Compound
GHRH (Growth Hormone-Releasing Hormone): The 44-amino-acid hypothalamic hormone that tells the pituitary to release growth hormone; sermorelin and tesamorelin are analogs.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.