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Effects of growth hormone replacement on physical performance and body composition in GH deficient adults.
Plain-language guide to PMID 10468965 (1999): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 10468965
- Journal
- Clinical endocrinology
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Rodríguez-Arnao J et al. (5 authors)
- DOI
- 10.1046/j.1365-2265.1999.00737.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.
Adults with GH deficiency complain frequently of low energy levels resulting in a low perceived quality of life.
The aims of this study were to determine the effects of GH replacement on physical performance and body composition in GH deficient (GHD) adults.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Thirty-five GHD adults (17F), mean age 39.8 years (range 21.1-59.9), on conventional replacement therapy as required.
Maximum aerobic capacity was measured using an incremental walking test to volitional exhaustion on a motorized treadmill.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Some participants received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.
Quadriceps muscle strength was assessed by measuring maximum voluntary contractions and body composition by dual energy X-ray absorptiometry (DEXA).
What Was Measured
The subject headings attached to it are Absorptiometry, Photon, Body Composition, Exercise Test, Exercise Tolerance, Growth Hormone, Hormone Replacement Therapy and Human Growth Hormone.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The abstract goes on to report its results in about 14 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 1999 (Clinical endocrinology), a journal based in England.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.