Growth hormone bioactivity and immunoactivity in tall children.

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.

To investigate the reason for these conflicting results, the researchers evaluated growth hormone (GH) secretion using different assays as well as GH-binding protein and insulin-like growth factor-I (IGF-I) concentrations in tall children.

Why It Was Studied

In subjects with constitutional tall stature, both low and high GH response to stimulation tests have been observed when measured by commercial kits.

Considering the highest serum GH levels as measured by IFMA, the 22 tall subjects were divided into two groups: group A including 16 children with blunted serum GH peak levels (5.78+/-0.68 ng/ml) and group B including 6 subjects with normal serum GH peak values (15.73+/-1.56 ng/ml).

Who Took Part

According to the abstract, 22 children were involved.

The age groups tagged for this paper are young children, children and teenagers, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

Serum IGF-I values were evaluated by RIA.

Circulating low affinity (LA) and high affinity (HA) GH-binding proteins (GHBPs) were evaluated by FPLC gel filtration.

What Was Measured

In subjects with constitutional tall stature, both low and high GH response to stimulation tests have been observed when measured by commercial kits.

Considering the highest serum GH levels as measured by IFMA, the 22 tall subjects were divided into two groups: group A including 16 children with blunted serum GH peak levels (5.78+/-0.68 ng/ml) and group B including 6 subjects with normal serum GH peak values (15.73+/-1.56 ng/ml).

PubMed files the paper under topics including Arginine, Body Height, Carrier Proteins, Human Growth Hormone, Insulin, Insulin-Like Growth Factor I and Levodopa.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 22 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1999 (Journal of endocrinological investigation), a journal based in Italy.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.