Metabolic and immunologic effects of insulin lispro in gestational diabetes

What Was Tested

The paper reports a study of Insulin Lispro, published as a randomized controlled trial.

In addition, 10 patients received continuous intravenous insulin (4 lispro, 6 regular human insulin) and dextrose infusions intrapartum to assess placental insulin transfer.

Who Took Part

The study group was 42 women.

The age groups tagged for this paper are adults, women only.

The researchers compared the metabolic and immunologic effects of insulin lispro and regular human insulin in 42 women >18 years of age diagnosed with gestational diabetes by oral glucose tolerance testing at 14-32 weeks of gestation.

Patients were randomized to receive regular human insulin or insulin lispro before consuming a test meal.

How the Study Was Run

The researchers set it up as a randomized study.

The women were allocated by chance, so the Insulin Lispro group and the comparison group should start out alike.

Serum insulin, blood glucose, and C-peptide concentrations were measured.

Throughout the remainder of gestation, patients received premeal insulin lispro or regular human insulin combined with basal insulin and performed blood glucose self-monitoring before and after each meal.

Insulin antibodies and HbA1c were determined at enrollment and 6 weeks later.

What Was Measured

PubMed files the paper under topics including Antibody Formation, Blood Glucose Self-Monitoring, Cross Reactions, Diabetes, Gestational, Hypoglycemic Agents, Insulin and Insulin Lispro.

What This Means in Plain Language

The paper is a randomized study of Insulin Lispro in 42 women.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1999 (Diabetes care), a journal based in United States.

More context: the Insulin Lispro compound page, all human trials.