Association and linkage between an insulin-like growth factor-1 gene polymorphism and fat free mass in the HERITAGE Family Study

What Was Tested

Researchers studied IGF-1 LR3 in this controlled clinical trial publication.

To investigate the relationship between a DNA microsatellite marker in the insulin-like growth factor-1 (IGF-1) gene and body composition phenotypes before and following exposure to 20 weeks of aerobic exercise training in the HERITAGE Family Study.

Who Took Part

According to the abstract, 502 individuals were involved.

PubMed indexes the participants as teenagers, adults and middle-aged adults, both men and women.

A maximum of 502 Caucasian individuals (99 families; 190 parents and 312 adult offspring).

How the Study Was Run

A controlled intervention study: fat mass (FM), percentage body fat (%FAT), fat free mass (FFM), body mass index (BMI) and abdominal visceral fat (AVF) at baseline (B) and in response to training (delta=post minus pre-training value) were measured.

Association and sib-pair linkage studies were undertaken.

The polymorphism was typed by polymerase chain reaction and DNA sequencer.

The body composition phenotypes were determined from the underwater weighing method, and AVF was assessed by computerized tomography scan.

What Was Measured

Topics PubMed links to this paper include Analysis of Variance, Arizona, Body Composition, DNA, DNA Primers, Dinucleotide Repeats and Exercise.

What This Means in Plain Language

This is a controlled clinical trial of IGF-1 LR3 in 502 individuals.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1999 (International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity), a journal based in England.

More context: the IGF-1 LR3 compound page, all human trials.