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Comparison of adrenocorticotropin (ACTH) stimulation tests and insulin hypoglycemia in normal humans: low dose, standard high dose, and 8-hour ACTH-(1-24) infusion tests
Plain-language guide to PMID 10523009 (1999): single-blind randomized controlled trial study of ACTH (Corticotropin) and Cosyntropin.
Key Facts
- PMID
- 10523009
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Nye EJ et al. (7 authors)
- DOI
- 10.1210/jcem.84.10.6062
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ACTH (Corticotropin) and Cosyntropin.
The insulin hypoglycemia test is widely regarded as the gold standard dynamic stimulation test of the hypothalamo-pituitary-adrenal (HPA) axis that provides the most reliable assessment of HPA axis integrity and reserve.
Alternatively, a prolonged infusion of ACTH causes a continuing rise in plasma cortisol levels that may predict the adrenals' capacity to respond to severe ongoing stress.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and single-blind study.
Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Only one side, usually the participants, was kept unaware of whether ACTH (Corticotropin) was given.
What Was Measured
The insulin hypoglycemia test is widely regarded as the gold standard dynamic stimulation test of the hypothalamo-pituitary-adrenal (HPA) axis that provides the most reliable assessment of HPA axis integrity and reserve.
Alternatively, a prolonged infusion of ACTH causes a continuing rise in plasma cortisol levels that may predict the adrenals' capacity to respond to severe ongoing stress.
The subject headings attached to it are Adrenocorticotropic Hormone, Chromatography, High Pressure Liquid, Cosyntropin, Fluorescence Polarization Immunoassay, Hydrocortisone, Hypoglycemia and Insulin.
What This Means in Plain Language
The paper is a randomized and single-blind study of ACTH (Corticotropin) and Cosyntropin.
The publication is from 1999 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the Cosyntropin compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
Cosyntropin: A synthetic 24-amino-acid fragment of ACTH (also tetracosactide, Synacthen) used mainly in the adrenal stimulation test.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.