Preservation of fertility and ovarian function and minimizing chemotherapy-induced gonadotoxicity in young women.

What It Covers

The paper reports a study of Antineoplastic Agents, published as a review.

Three major topics are reviewed.

They include the following: (1) the role of chemotherapy in the treatment of malignant and nonmalignant disease in young women, the types of chemotherapy and their gonadal effects (differing between ovaries and testes) in both human and other species, and the reasons for differences in the outcomes of various studies; (2) the human experience with GnRH-agonist therapy for minimizing chemotherapy-associated gonadotoxicity; and (3) inhibin measurements in young women treated by chemotherapy and in perimenopausal patients and those with impending premature ovarian failure (POF).

Who the Included Studies Covered

PubMed tags the participants as women only.

To characterize the correlation with ovarian function after gonadotoxic chemotherapy for Hodgkin or non-Hodgkin lymphoma in young women, the immunoreactive inhibin-A concentrations in the sera of these patients were measured before, during, and after the gonadotoxic chemotherapy.

What Was Measured

They include the following: (1) the role of chemotherapy in the treatment of malignant and nonmalignant disease in young women, the types of chemotherapy and their gonadal effects (differing between ovaries and testes) in both human and other species, and the reasons for differences in the outcomes of various studies; (2) the human experience with GnRH-agonist therapy for minimizing chemotherapy-associated gonadotoxicity; and (3) inhibin measurements in young women treated by chemotherapy and in perimenopausal patients and those with impending premature ovarian failure (POF).

The subject headings attached to it are Antineoplastic Agents, Drug Administration Routes, Fertility, Inhibins, Ovary, Primary Ovarian Insufficiency and Receptors, LHRH.

What This Means in Plain Language

This is a review of Antineoplastic Agents.

The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1999 (Journal of the Society for Gynecologic Investigation), a journal based in United States.

More context: all human trials.