Desmopressin resistant enuresis: pathogenetic and therapeutic considerations

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

The researchers tested the role of the bladder in the pathogenesis of desmopressin resistant enuresis by evaluating the influence of urine production on the timing of the enuretic event and the response to anticholinergic medication.

Who Took Part

According to the abstract, 33 children were involved.

The age groups tagged for this paper are children and teenagers, both men and women.

The time of enuresis or nocturia was documented.

Nonresponders to this regimen and the remainder of the children were offered anticholinergic treatment.

How the Study Was Run

The researchers set it up as a randomized, double-blind, open-label, placebo-controlled and crossover study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

Everyone knew when Vasopressin was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Some children received a placebo instead of Vasopressin, giving a reference point.

What Was Measured

Topics PubMed links to this paper include Deamino Arginine Vasopressin, Drug Resistance, Enuresis and Renal Agents.

What This Means in Plain Language

The paper is a randomized, double-blind and open-label study of Vasopressin and Desmopressin in 33 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1999 (The Journal of urology), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.