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Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists
Plain-language guide to PMID 10575251 (1999): pilot clinical trial, phase i study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 2,000 infants.
Key Facts
- PMID
- 10575251
- Journal
- Developmental neuroscience
- Year
- 1999
- Study type
- Clinical Trial, Phase I
- Authors
- Baram TZ et al. (4 authors)
- DOI
- 10.1159/000017407
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone), published as a clinical trial, phase i.
The costs of IS in terms of loss of lifetime productivity and emotional and financial burdens on families are enormous.
However, the severe side effects of ACTH require development of better treatments for IS.
Who Took Part
The abstract describes 2,000 infants taking part.
The age groups tagged for this paper are infants and young children, both men and women.
With FDA approval, alpha-helical CRH, a competitive antagonist of the peptide, was given as a phase I trial to 6 infants with IS who have either failed conventional treatment or who have suffered a recurrence.
The study was performed at the Clinical Research Center of the Childrens Hospital, Los Angeles.
How the Study Was Run
The researchers set it up as a pilot study.
It is described as a pilot, a small early test of whether a larger ACTH (Corticotropin) study would be practical.
The effects of alpha-helical CRH on autonomic parameters (blood pressure, pulse, temperature, respiration) were determined.
In addition, immediate and short-term effects on ACTH and cortisol and on electrolytes and glucose were examined.
What Was Measured
Topics PubMed links to this paper include Adrenocorticotropic Hormone, Autonomic Nervous System, Corticotropin-Releasing Hormone, Hormone Antagonists, Hydrocortisone, Models, Neurological and Pilot Projects.
What This Means in Plain Language
The paper is a pilot study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 2,000 infants.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1999 (Developmental neuroscience), a journal based in Switzerland.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.