Quantitative growth hormone secretion and final adult height

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The relationship of quantitative GH secretion to height, growth velocity and puberty is complex and has been the subject of extensive study in children.

This study was designed to relate quantitative GH secretion to final height.

Who Took Part

The age groups tagged for this paper are adults, men only.

Twenty tall (> 183 cm, 90th centile for adult height) and 20 short (< 166 cm, 10th centile) postpubertal men who had recently completed linear growth (age range 18-27 years).

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

Spontaneous nocturnal GH secretion was assessed by 20 minute sampling from 2100 h until 0600 h.

GH was measured by IRMA.

Analysis was by comparison of peak GH response and area under the curve (AUC).

GH profiles were further analysed using the 'pulsar' programme.

What Was Measured

Topics PubMed links to this paper include Area Under Curve, Body Height, Cholinesterase Inhibitors, Growth Hormone, Insulin, Pyridostigmine Bromide and Sermorelin.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1999 (Clinical endocrinology), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.