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Corticotropin-releasing hormone: a potent androgen secretagogue in girls with hyperandrogenism after precocious pubarche
Plain-language guide to PMID 10599726 (1999): crossover randomized controlled trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 12 girls.
Key Facts
- PMID
- 10599726
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Ibáñez L et al. (4 authors)
- DOI
- 10.1210/jcem.84.12.6239
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone), published as a randomized controlled trial.
CRH is an adrenal androgen secretagogue in men and has been proposed as a candidate regulator of adrenarche.
CRH also affects androgen production by theca cells and may be involved in the pathogenesis of ovarian hyperandrogenism (OH).
Who Took Part
The study group was 12 girls.
PubMed indexes the participants as teenagers and adults, women only.
How the Study Was Run
In design terms this was a randomized and crossover study.
Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.
In the crossover set-up each of the girls took both ACTH (Corticotropin) and the comparison in turn, acting as their own control.
Serum LH, FSH, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEAS) were measured at time 0, 3, 6, and 24 h, and ACTH and 17-OHP were measured at time 0, 6, and 24 h.
What Was Measured
In adolescent girls with a history of PP, the researchers assessed the early androgen response to CRH, as well as the CRH effect on the late ovarian response to GnRH agonist.
The subject headings attached to it are Adrenocorticotropic Hormone, Androgens, Body Mass Index, Corticotropin-Releasing Hormone, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Dexamethasone.
What This Means in Plain Language
The paper is a randomized and crossover study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 12 girls.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1999 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.