Effect of magnesium infusion on bleeding time in healthy male volunteers.

What Was Tested

Researchers studied Magnesium Sulfate in this randomized controlled trial publication.

Intravenous magnesium has proved to be valuable in the treatment of cardiac arrhythmias and eclampsia, but the specific mode of action is not established.

In this study the effect of magnesium sulphate (MgSO4) infusion on bleeding time and endogenous prostacyclin (PGI2) production in healthy male volunteers was investigated.

Who Took Part

PubMed indexes the participants as teenagers and adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Magnesium Sulfate study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Magnesium Sulfate, so expectations could not easily colour the readings.

Some participants received a placebo instead of Magnesium Sulfate, giving a reference point.

Each person switched between Magnesium Sulfate and the comparison at some point, usually with a gap in between.

What Was Measured

PubMed files the paper under topics including 6-Ketoprostaglandin F1 alpha, Bleeding Time, Blood Pressure, Epoprostenol, Heart Rate, Magnesium Sulfate and Reproducibility of Results.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium Sulfate.

The publication is from 1999 (Scandinavian journal of clinical and laboratory investigation), a journal based in England.

More context: all human trials.