Effect kinetics of desmopressin-induced platelet retention in healthy volunteers treated with aspirin or placebo

What Was Tested

Researchers studied Vasopressin and Desmopressin in this randomized controlled trial publication.

This study aimed to determine the kinetics of platelet function responses induced by desmopressin in healthy volunteers treated with aspirin or placebo.

Another aim was to correlate platelet responses to changes of von Willebrand factor (vWF) in plasma.

Why It Was Studied

Desmopressin is often used for haemostatic treatment in platelet dysfunction, but the effect kinetics of platelet responses and the mechanism of action are poorly known.

After about 3 h platelet function had returned to baseline.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.

In the crossover set-up each of the participants took both Vasopressin and the comparison in turn, acting as their own control.

What Was Measured

PubMed files the paper under topics including Antigens, Aspirin, Bleeding Time, Deamino Arginine Vasopressin, Hemostatics, Platelet Adhesiveness and Platelet Count.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin.

The publication is from 2000 (Haemophilia : the official journal of the World Federation of Hemophilia), a journal based in England.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.