Addition of gonadotrophin-releasing hormone agonist and/or two inseminations with husband's sperm do not improve the pregnancy rate in superovulated cycles.

What Was Tested

The paper reports a study of Gonadotropin-Releasing Hormone, published as a randomized controlled trial.

A prospective randomized study was performed to evaluate the addition of a gonadotropin releasing hormone agonist (GnRH-a) during treatment with human menopausal gonadotropins (hMG) in cycles with artificial inseminations with husband's washed sperm (AIH).

Why It Was Studied

The researchers also compared the pregnancy rate per cycle after one versus two AIHs.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

A total of 172 couples with unexplained infertility (n=88), endometriosis (n=39), or cervical (n=24) or male (n=21) factors were included, of whom 161 fulfilled the inclusion criteria and treatment.

Eighty-one women were treated with GnRH-a/hMG and another 80 with hMG only, respectively.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Gonadotropin-Releasing Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The researchers designed a 22 factorial trial.

What Was Measured

Topics PubMed links to this paper include Gonadotropin-Releasing Hormone, Insemination, Artificial, Homologous, Menotropins, Ovulation Induction, Pregnancy Outcome and Superovulation.

What This Means in Plain Language

The paper is a randomized study of Gonadotropin-Releasing Hormone.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2000 (Acta obstetricia et gynecologica Scandinavica), a journal based in United States.

More context: all human trials.