No effect of copper supplementation on biochemical markers of bone metabolism in healthy adults

What Was Tested

This randomized controlled trial paper looks at Copper (Supplement).

The influence of Cu supplementation of the usual diet for 6 weeks on biochemical markers of bone turnover and on putative indices of Cu status was investigated in healthy adults (twelve male and twelve female) aged 22-46 years, who participated in a double-blind placebo-controlled repeated crossover study.

During baseline and on the last day of each dietary period, fasting morning first-void urine and fasting blood serum, plasma and erythrocytes were collected.

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

As a double-blind Copper (Supplement) study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.

In the crossover set-up each of the participants took both Copper (Supplement) and the comparison in turn, acting as their own control.

The timeline in the abstract includes 6 weeks.

What Was Measured

PubMed files the paper under topics including Biomarkers, Bone Remodeling, Bone and Bones, Copper, Dietary Supplements, Erythrocytes and Nutritional Status.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) over 6 weeks.

The publication is from 1999 (The British journal of nutrition), a journal based in England.

More context: the Copper (Supplement) compound page, all human trials.