← Human Trials & Peer-Reviewed Studies
Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts
Plain-language guide to PMID 10657535 (1999): placebo-controlled randomized controlled trial study of TRH (Thyrotropin-Releasing Hormone) in 11 subjects.
Key Facts
- PMID
- 10657535
- Journal
- Neuropeptides
- Year
- 1999
- Study type
- Randomized Controlled Trial
- Authors
- Vescovi PP et al. (2 authors)
- DOI
- 10.1054/npep.1999.0773
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of TRH (Thyrotropin-Releasing Hormone), published as a randomized controlled trial.
During cocaine addiction the hypothalamus-pituitary axis is widely affected and a blunted response of thyroid stimulating hormone (TSH) to thyroid releasing hormone (TRH) consistent with a hyperthyroid state has been observed.
Since the thyroid status can affect the release of growth hormone (GH) the authors evaluated TSH and GH responses to TRH in cocaine addicts at the time of drug withdrawal and 30 days after.
Who Took Part
The abstract describes 11 subjects taking part.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
The subjects were allocated by chance, so the TRH (Thyrotropin-Releasing Hormone) group and the comparison group should start out alike.
Some subjects received a placebo instead of TRH (Thyrotropin-Releasing Hormone), giving a reference point.
The methods mention a period of 30 days.
What Was Measured
Since the thyroid status can affect the release of growth hormone (GH) the authors evaluated TSH and GH responses to TRH in cocaine addicts at the time of drug withdrawal and 30 days after.
TRH and placebo tests were performed at random at 5 day intervals at the time of drug withdrawal and after 30 days.
PubMed files the paper under topics including Chronic Disease, Cocaine-Related Disorders, Human Growth Hormone, Substance Withdrawal Syndrome, Thyroid Gland, Thyrotropin and Thyrotropin-Releasing Hormone.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of TRH (Thyrotropin-Releasing Hormone) in 11 subjects over 30 days.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1999 (Neuropeptides), a journal based in Netherlands.
More context: the TRH (Thyrotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compound
TRH (Thyrotropin-Releasing Hormone): A 3-amino-acid hypothalamic hormone (protirelin) that triggers TSH and prolactin release.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.