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Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers.
Plain-language guide to PMID 10702174 (2000): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 219 children.
Key Facts
- PMID
- 10702174
- Journal
- The American journal of clinical nutrition
- Year
- 2000
- Study type
- Randomized Controlled Trial
- Authors
- Muñoz EC et al. (5 authors)
- DOI
- 10.1093/ajcn/71.3.789
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The objective of this study was to investigate the effect of supplementation with iron, zinc, or both on vitamin A and its metabolically related proteins retinol binding protein (RBP) and transthyretin.
Why It Was Studied
The coexistence of multiple micronutrient deficiencies is a widespread public health problem in many regions of the world.
Interactions between zinc deficiency and vitamin A metabolism have been reported but no longitudinal studies have evaluated the effect of iron deficiency on vitamin A.
Who Took Part
The study group was 219 children.
PubMed indexes the participants as infants and young children.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the children nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
Interactions between zinc deficiency and vitamin A metabolism have been reported but no longitudinal studies have evaluated the effect of iron deficiency on vitamin A.
PubMed files the paper under topics including Dietary Supplements, Ferritins, Hemoglobins, Iron, Iron Deficiencies, Iron, Dietary and Longitudinal Studies.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 219 children.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2000 (The American journal of clinical nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.