Role of GnRH agonists in managing proximal fallopian tube obstruction.

What Was Tested

This randomized controlled trial looks at Leuprolide and Gonadotropin-Releasing Hormone.

To assess the response of proximal fallopian tube obstruction to a medically induced hypoestrogenic state after control for spasm at the uterotubal ostium.

Who Took Part

According to the abstract, 14 patients were involved.

By PubMed's age tags, the people studied were adults, women only.

Twenty-one infertile women with unilateral or bilateral proximal tubal obstruction previously diagnosed by standard hysterosalpingography or laparoscopic chromotubation were randomized into two groups in a 2:1 design.

Group II, seven patients (11 occluded tubes), was administered a placebo.

How the Study Was Run

In design terms this was a randomized, placebo-controlled and pilot study.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Leuprolide group a baseline to be compared against.

It is described as a pilot, a small early test of whether a larger Leuprolide study would be practical.

This was a prospective, randomized, placebo-controlled, pilot study in a tertiary care, university-affiliated infertility practice.

What Was Measured

Topics PubMed links to this paper include Fallopian Tube Diseases, Fallopian Tubes, Fertility Agents, Female, Gonadotropin-Releasing Hormone, Infertility, Female, Leuprolide and Ovary.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and pilot study of Leuprolide and Gonadotropin-Releasing Hormone in 14 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2000 (The Journal of reproductive medicine), a journal based in United States.

More context: the related Leuprolide library page, all human trials.