Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability

What Was Tested

Researchers studied IGF-1 LR3 in this randomized controlled trial publication.

Both insulin-like growth factor (IGF)-1 and insulin-like growth factor-binding protein (IGFBP)-1 are synthesized by the liver.

It is well known that chronic alcohol abuse impairs liver function, but less is known about how an acute intake of moderate quantities of alcohol affects hepatic production of IGF-1 and IGFBP-1.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

Eight healthy subjects were tested on two occasions.

On another occasion (experiment B), three 150-ml drinks of diluted ethanol were given instead of water.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the IGF-1 LR3 group and the comparison group should start out alike.

Experiments A and B were performed in random order, 1 week apart.

Blood samples were collected before, during and after the drinks over a period of 7 h (08.00-15.00 h).

One blood sample was also drawn at 08.00 h the following day.

Blood glucose and serum concentrations of ethanol, insulin, growth hormone (GH), IGF-1 and IGFBP-1 were determined.

What Was Measured

PubMed files the paper under topics including Alcohol Drinking, Blood Glucose, Ethanol, Growth Hormone, Insulin, Insulin-Like Growth Factor Binding Protein 1 and Insulin-Like Growth Factor I.

What This Means in Plain Language

The paper is a randomized study of IGF-1 LR3.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2000 (Clinical endocrinology), a journal based in England.

More context: the IGF-1 LR3 compound page, all human trials.