A synergistic effect of a daily supplement for 1 month of magnesium plus vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

Forty-four women with an average age of 32 years took part in the study.

Symptoms were grouped into six categories: anxiety, craving, depression, hydration, other, and total.

Who Took Part

The abstract describes 44 women taking part.

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the women and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

In the crossover set-up each of the women took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

What Was Measured

Topics PubMed links to this paper include Anxiety, Drug Synergism, Magnesium, Premenstrual Syndrome and Pyridoxine.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 44 women.

The publication is from 2000 (Journal of women's health & gender-based medicine), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.