A randomized comparison of danazol and leuprolide acetate suppression of serum-soluble CD23 levels in endometriosis

What Was Tested

The paper reports a study of Leuprolide in the context of endometriosis, published as a randomized controlled trial.

To determine the effects of treatment with danazol and leuprolide acetate depot on serum-soluble CD23 concentrations in women with endometriosis.

Who Took Part

The abstract describes 20 women taking part.

The age groups tagged for this paper are teenagers and adults, women only.

This randomized trial involved 20 women 18-42 years old with regular menses and known pelvic endometriosis who were recruited from a university hospital between 1993 and 1998.

Blood-soluble CD23 levels were measured before treatment, during the last 15 days of the 6-month treatment course, and 3 months after treatment.

How the Study Was Run

The design is described as randomized and double-blind.

Random assignment meant chance, not the researchers, decided who got Leuprolide and who got the comparison, which limits bias.

Neither the women nor the staff measuring them knew who was on Leuprolide, so expectations could not easily colour the readings.

Only one blood sample was taken from ten women without endometriosis, between the 5th and 7th days of their menstrual cycles.

For statistical analysis, the researchers used independent and paired t tests with the Pearson correlation coefficient.

What Was Measured

The subject headings attached to it are Danazol, Endometriosis, Estrogen Antagonists, Fertility Agents, Female, Leuprolide and Receptors, IgE.

What This Means in Plain Language

The paper is a randomized and double-blind study of Leuprolide in 20 women in people with endometriosis.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2000 (Obstetrics and gynecology), a journal based in United States.

More context: the Leuprolide compound page, Endometriosis research.