Postnatal changes of extracellular volume, atrial natriuretic factor, and diuresis in a randomized controlled trial of high-frequency oscillatory ventilation versus intermittent positive-pressure ventilation in premature infants <30 weeks gestation

What Was Tested

Researchers studied ANP (Atrial Natriuretic Peptide) in this randomized controlled trial publication.

Who Took Part

According to the abstract, 15 infants were involved.

How the Study Was Run

In design terms this was a randomized study.

The infants were allocated by chance, so the ANP (Atrial Natriuretic Peptide) group and the comparison group should start out alike.

Prospective, randomized, controlled clinical trial.

University hospital, Level III neonatal intensive care unit.

Premature infants <30 wks gestation requiring intubation for respiratory distress syndrome within the first 6 hrs of life; 15 infants (gestational age, 26 [24-29] wks, birth weight 814 [452-1340] g) were randomized to HFOV, 19 infants (gestational age 27 [24-39] wks, birth weight 930 [644-1490] g) to IPPV.

The randomized mode of ventilation was assigned within 1 hr after intubation.

IPPV rates were > or =60/min.

What Was Measured

Topics PubMed links to this paper include Atrial Natriuretic Factor, Diuresis, Extracellular Space, Gestational Age, High-Frequency Ventilation, Infant, Premature and Intermittent Positive-Pressure Ventilation.

What This Means in Plain Language

The paper is a randomized study of ANP (Atrial Natriuretic Peptide) in 15 infants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2000 (Critical care medicine), a journal based in United States.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.