Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans.

What Was Tested

Researchers studied Proglumide in this randomized controlled trial publication.

Cholecystokinin (CCK) interacts with neural signals to induce satiety in several species, but the mechanisms are unclear.

The researchers therefore tested the hypothesis that alimentary CCK (CCK-A) receptors mediate the interaction of CCK with an appetizer on food intake in humans.

Who Took Part

The study group was 16 men.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Proglumide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the men nor the staff measuring them knew who was on Proglumide, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Proglumide group a baseline to be compared against.

In the crossover set-up each of the men took both Proglumide and the comparison in turn, acting as their own control.

What Was Measured

The researchers therefore tested the hypothesis that alimentary CCK (CCK-A) receptors mediate the interaction of CCK with an appetizer on food intake in humans.

The subject headings attached to it are Cholecystokinin, Eating, Energy Intake, Hunger, Proglumide, Receptor, Cholecystokinin A and Receptors, Cholecystokinin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Proglumide in 16 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2000 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.

More context: all human trials.