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Subcutaneously administered Repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment. Repronex SC, IVF Study Group
Plain-language guide to PMID 10899500 (2000): open-label randomized controlled trial study of HMG (Human Menopausal Gonadotropin) and Leuprolide, female fertility.
Key Facts
- PMID
- 10899500
- Journal
- Fertility and sterility
- Year
- 2000
- Study type
- Randomized Controlled Trial
- Authors
- Gocial B et al. (4 authors)
- DOI
- 10.1016/s0015-0282(00)00605-1
What This Study Did, in Plain Language
What Was Tested
Researchers studied HMG (Human Menopausal Gonadotropin) and Leuprolide in the context of female fertility in this randomized controlled trial publication.
Who Took Part
PubMed indexes the participants as teenagers and adults, women only.
Premenopausal women with regular ovulatory menstrual cycles undergoing IVF for infertility attributable to tubal factors, endometriosis (stage I or II), or unknown factors.
Down-regulation with leuprolide acetate followed by up to 12 days of treatments with gonadotropins, hCG administration, oocyte retrieval, and embryo transplant.
How the Study Was Run
In design terms this was a randomized, open-label, multicenter and parallel-group study.
The participants were allocated by chance, so the HMG (Human Menopausal Gonadotropin) group and the comparison group should start out alike.
Everyone knew when HMG (Human Menopausal Gonadotropin) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.
More than one site took part, so the participants came from several places.
Groups ran in parallel: each of the participants stayed in one arm throughout.
The methods mention a period of 12 days.
Open-label, randomized, parallel-group, multicenter study.
Fifteen academic and private fertility clinics with IVF experience.
What Was Measured
PubMed files the paper under topics including Down-Regulation, Embryo Transfer, Fertility Agents, Female, Fertilization in Vitro, Gonadotropins, Leuprolide and Menotropins.
What This Means in Plain Language
The paper is a randomized, open-label and multicenter study of HMG (Human Menopausal Gonadotropin) and Leuprolide in people with female fertility over 12 days.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2000 (Fertility and sterility), a journal based in United States.
More context: the HMG (Human Menopausal Gonadotropin) compound page and the Leuprolide compound page, Female fertility research.
Our Notes on the Compounds
HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.
Related Pages
- Female fertility research
- HMG (Human Menopausal Gonadotropin) in the library
- Leuprolide in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.