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Pilot study of combined blockade of the renin-angiotensin system in essential hypertensive patients.
Plain-language guide to PMID 10954007 (2000): double-blind randomized controlled trial of Angiotensin II and Enalapril in 177 patients.
Key Facts
- PMID
- 10954007
- Journal
- Journal of hypertension
- Year
- 2000
- Study type
- Randomized Controlled Trial
- Authors
- Azizi M et al. (7 authors)
- DOI
- 10.1097/00004872-200018080-00020
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Angiotensin II and Enalapril.
To investigate whether the same additive hemodynamic effects occur in patients with hypertension and to verify the safety of such an approach.
Why It Was Studied
Additive hemodynamic effects of combined blockade of the renin-angiotensin system by an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist have been observed in sodium-depleted normotensive volunteers and in patients with congestive heart failure.
Who Took Part
The abstract describes 177 patients taking part.
The age groups tagged for this paper are teenagers, adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled, multicenter, parallel-group and pilot study.
The patients were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
Blinding on both sides kept the patients and researchers unaware of who received Angiotensin II.
Some patients received a placebo instead of Angiotensin II, giving a reference point.
Running at several centres spread the Angiotensin II study over different clinics and patient groups.
Multicenter, randomized, double-blind, parallel-group, pilot study.
What Was Measured
PubMed files the paper under topics including Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Biomarkers, Blood Pressure, Enalapril and Hypertension.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II and Enalapril in 177 patients.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2000 (Journal of hypertension), a journal based in Netherlands.
More context: the related Angiotensin II library page, all human trials.
Related Library Page
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.