← Human Trials & Peer-Reviewed Studies
Growth hormone (GH) substitution for one year normalizes elevated GH-binding protein levels in GH-deficient adults secondary to a reduction in body fat. A placebo-controlled trial.
Plain-language guide to PMID 10987677 (1998): parallel-group controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 10987677
- Journal
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Year
- 1998
- Study type
- Controlled Clinical Trial
- Authors
- Fisker S et al. (7 authors)
- DOI
- 10.1016/s1096-6374(98)80100-7
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a controlled clinical trial.
The high affinity growth hormone binding protein (GHBP) in human serum derives from the extracellular domain of the GH receptor.
It is well known that fat mass correlates positively to GHBP levels, but it is uncertain whether GH secretory status influences GHBP levels.
Who Took Part
By PubMed's age tags, the people studied were adults and middle-aged adults.
How the Study Was Run
The researchers set it up as a placebo-controlled and parallel-group study.
Some participants received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.
Groups ran in parallel: each of the participants stayed in one arm throughout.
What Was Measured
It is well known that fat mass correlates positively to GHBP levels, but it is uncertain whether GH secretory status influences GHBP levels.
The participants underwent anthropometric measurements [body mass index (BMI), waist/hip ratio (W/H)], computer-tomography (CT-scan) of femoral and abdominal regions, dual-energy X-ray absorptiometry (DEXA-scan), and bioimpedance (BIA), as well as blood sampling.
The subject headings attached to it are Adipose Tissue, Analysis of Variance, Body Composition, Body Constitution, Body Mass Index, Carrier Proteins and Dwarfism, Pituitary.
What This Means in Plain Language
The paper is a placebo-controlled and parallel-group study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The publication is from 1998 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.