Neuroendocrine control of pulsatile growth hormone release in the human: relationship with gender.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this review publication.

The sex differences in GH axis activity are highly specific mechanistically, and namely entail the mass of GH secreted per burst (greater in women than men), and the orderliness of the 24-hour GH release process (less orderly pattern in women).

Oestrogen, directly or indirectly (e.g. via long-term changes in visceral and subcutaneous fat distribution), serves as the proximate mediator of many gender differences, and probably mediates most of the acute sex-steroid effects of both testosterone and oestradiol on the human GH-IGF-I axis.

Who the Included Studies Covered

PubMed tags the participants as both men and women.

What Was Measured

Oestrogen, directly or indirectly (e.g. via long-term changes in visceral and subcutaneous fat distribution), serves as the proximate mediator of many gender differences, and probably mediates most of the acute sex-steroid effects of both testosterone and oestradiol on the human GH-IGF-I axis.

Topics PubMed links to this paper include Androgens, Estrogens, Ethnicity, Feedback, Growth Hormone-Releasing Hormone, Human Growth Hormone and Menstrual Cycle.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 1998 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.