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Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise

Plain-language guide to PMID 11004017 (2000): randomized controlled clinical trial study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2 in 9 men.

Key Facts

PMID
11004017
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
Year
2000
Study type
Controlled Clinical Trial
Authors
Wideman L et al. (8 authors)
DOI
10.1152/ajpregu.2000.279.4.R1467

What This Study Did, in Plain Language

What Was Tested

This controlled clinical trial paper looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2.

The researchers investigated the ability of exercise, a multipathway, potent, physiological stimulus for GH release, to alter the synergistic interaction of L-arginine (A) and GH-related peptide (GHRP)-2 (G) observed at rest and the ability of gender to further modulate this putative interaction.

Measures of GH release were logarithmically transformed for statistical analysis.

Who Took Part

The abstract describes 9 men taking part.

PubMed indexes the participants as adults, both men and women.

How the Study Was Run

The design is described as randomized.

The men were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

What Was Measured

Measures of GH release were logarithmically transformed for statistical analysis.

The subject headings attached to it are Analysis of Variance, Arginine, Drug Synergism, Energy Metabolism, Exercise, Follicular Phase and Hormones.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRP-2 in 9 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2000 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the GHRP-2 compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

GHRP-2: A synthetic growth hormone secretagogue that activates the ghrelin receptor and can increase appetite.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.