Effects of growth hormone on leptin metabolism and energy expenditure in hemodialysis patients with protein-calorie malnutrition.

What Was Tested

This clinical trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The relationships among growth hormone (GH), leptin, and resting energy expenditure (REE) are not understood.

The present study evaluated the arterial levels and the forearm exchange of leptin, as well as the REE of the same patients during their participation in the same study, in four sequential 6-wk periods: I, baseline; II, GH treatment; III, washout; and IV, GH + intradialytic parenteral nutrition.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a crossover study.

Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.

What Was Measured

The present study evaluated the arterial levels and the forearm exchange of leptin, as well as the REE of the same patients during their participation in the same study, in four sequential 6-wk periods: I, baseline; II, GH treatment; III, washout; and IV, GH + intradialytic parenteral nutrition.

Basal leptin levels were low (2.0 +/- 0.19 ng/L).

Topics PubMed links to this paper include Energy Metabolism, Human Growth Hormone, Insulin, Insulin-Like Growth Factor Binding Proteins, Leptin, Parenteral Nutrition and Protein-Energy Malnutrition.

What This Means in Plain Language

The paper is a crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 2000 (Journal of the American Society of Nephrology : JASN), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.