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Signs of sexual behaviour are not increased after subchronic treatment with LHRH in young men.
Plain-language guide to PMID 11070330 (2001): double-blind randomized controlled trial of Gonadotropin-Releasing Hormone in 20 men.
Key Facts
- PMID
- 11070330
- Journal
- Psychoneuroendocrinology
- Year
- 2001
- Study type
- Randomized Controlled Trial
- Authors
- Perras B et al. (4 authors)
- DOI
- 10.1016/s0306-4530(00)00031-7
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Gonadotropin-Releasing Hormone.
The present study aimed to assess a similar role of LHRH for sexuality in humans.
Why It Was Studied
Apart from its action as gonadotropin releasing factor, luteinizing hormone-releasing hormone (LHRH) is a potent regulator of sexual behaviour in animals.
Effects on sexuality were contrasted with those on eating motivation and general neurocognitive functioning, the latter being assessed in addition by tasks of divergent thinking and a motor perseveration test.
Who Took Part
According to the abstract, 20 men were involved.
By PubMed's age tags, the people studied were adults, men only.
Sexual desire and activity was assessed by a diary, ratings of women's attractiveness, a modified version of the Stroop colour naming task and a short term memory task.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The men were allocated by chance, so the Gonadotropin-Releasing Hormone group and the comparison group should start out alike.
As a double-blind Gonadotropin-Releasing Hormone study, the assignments were hidden from both participants and investigators until the end.
Some men received a placebo instead of Gonadotropin-Releasing Hormone, giving a reference point.
What Was Measured
Effects on sexuality were contrasted with those on eating motivation and general neurocognitive functioning, the latter being assessed in addition by tasks of divergent thinking and a motor perseveration test.
PubMed files the paper under topics including Affect, Cognition, Eating, Follicle Stimulating Hormone, Gonadotropin-Releasing Hormone, Luteinizing Hormone and Memory, Short-Term.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Gonadotropin-Releasing Hormone in 20 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2001 (Psychoneuroendocrinology), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.