Do former smokers respond to nicotine differently from never smokers? A pilot study.

What Was Tested

This randomized controlled trial looks at Therapeutic nicotine (patch, non-peptide).

To examine nicotine reinforcement, participants reported preferences among the gums, reported gum vs. money choices plus, on a fourth day, underwent a double-blind self-administration test.

Why It Was Studied

Nine former, 11 never, and 10 current smokers abstained from smoking for 16 h on each of 4 days.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, crossover and pilot study.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Therapeutic nicotine (patch, non-peptide) study, the assignments were hidden from both participants and investigators until the end.

In the crossover set-up each of the participants took both Therapeutic nicotine (patch, non-peptide) and the comparison in turn, acting as their own control.

It is described as a pilot, a small early test of whether a larger Therapeutic nicotine (patch, non-peptide) study would be practical.

What Was Measured

PubMed files the paper under topics including Nicotine, Pilot Projects, Reinforcement, Psychology, Smoking and Smoking Cessation.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Therapeutic nicotine (patch, non-peptide).

The publication is from 2000 (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco), a journal based in England.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.