A double-blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin

What Was Tested

The paper reports a study of Secretin, published as a randomized controlled trial.

Biologically derived porcine secretin has been used as a diagnostic agent in clinical gastrointestinal practice for many years.

Pure synthetic porcine secretin is now available for investigational clinical use.

Who Took Part

According to the abstract, 12 subjects were involved.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

The subjects were allocated by chance, so the Secretin group and the comparison group should start out alike.

As a double-blind Secretin study, the assignments were hidden from both participants and investigators until the end.

In the crossover set-up each of the subjects took both Secretin and the comparison in turn, acting as their own control.

Duodenal aspirates were analysed for total volume and for bicarbonate concentration.

Total bicarbonate output was calculated.

What Was Measured

Biologically derived porcine secretin has been used as a diagnostic agent in clinical gastrointestinal practice for many years.

PubMed files the paper under topics including Secretin and Swine.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Secretin in 12 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2000 (Alimentary pharmacology & therapeutics), a journal based in England.

More context: the Secretin compound page, all human trials.