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The release of antidiuretic hormone is appropriate in response to hypovolemia and/or sodium administration in children with severe head injury: a trial of lactated Ringer's solution versus hypertonic saline
Plain-language guide to PMID 11226092 (2001): randomized controlled trial study of Vasopressin.
Key Facts
- PMID
- 11226092
- Journal
- Anesthesia and analgesia
- Year
- 2001
- Study type
- Randomized Controlled Trial
- Authors
- Simma B et al. (6 authors)
- DOI
- 10.1097/00000539-200103000-00016
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin, published as a randomized controlled trial.
The researchers conducted an open, randomized, and prospective study to determine the effect of hypertonic saline on the secretion of antidiuretic hormone (ADH) and aldosterone in children with severe head injury (Glasgow coma scale <8).
Why It Was Studied
Thirty-one consecutive patients at a level III pediatric intensive care unit at a children's hospital received either lactated Ringer's solution (Ringer's group, n = 16) or hypertonic saline (Hypertonic Saline group, n = 15) over a 3-day period.
Head-injured children have appropriate levels of ADH.
Who Took Part
By PubMed's age tags, the people studied were infants, young children, children and teenagers.
How the Study Was Run
In design terms this was a randomized study.
The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
The timeline in the abstract includes 3 days.
What Was Measured
Thirty-one consecutive patients at a level III pediatric intensive care unit at a children's hospital received either lactated Ringer's solution (Ringer's group, n = 16) or hypertonic saline (Hypertonic Saline group, n = 15) over a 3-day period.
Head-injured children have appropriate levels of ADH.
PubMed files the paper under topics including Aldosterone, Craniocerebral Trauma, Hypovolemia, Isotonic Solutions, Ringer's Lactate, Saline Solution, Hypertonic and Sodium.
What This Means in Plain Language
The paper is a randomized study of Vasopressin over 3 days.
Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2001 (Anesthesia and analgesia), a journal based in United States.
More context: the Vasopressin compound page, all human trials.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.