Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism.

What Was Tested

The paper reports a study of Flutamide and Gonadotropin-Releasing Hormone, published as a randomized controlled trial.

The objective of this prospective randomized study was to evaluate and compare the hormonal and clinical effects of long-acting gonadotropin-releasing hormone (GnRH) agonist and a combination of GnRH agonist with combined oral contraceptive (COC) or flutamide in women with polycystic ovary syndrome (PCOS).

Why It Was Studied

Before, at the end and 6 months after the end of treatment, blood samples were drawn from all women (in early follicular phase in those with menstrual cycles) to measure ovarian and adrenal androgens, gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estradiol and estrone plasma levels.

Who Took Part

PubMed indexes the participants as adults, women only.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Flutamide and who got the comparison, which limits bias.

What Was Measured

Before, at the end and 6 months after the end of treatment, blood samples were drawn from all women (in early follicular phase in those with menstrual cycles) to measure ovarian and adrenal androgens, gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estradiol and estrone plasma levels.

PubMed files the paper under topics including Amenorrhea, Androgen Antagonists, Contraceptives, Oral, Combined, Cyproterone Acetate, Estradiol, Estradiol Congeners and Estrone.

What This Means in Plain Language

The paper is a randomized study of Flutamide and Gonadotropin-Releasing Hormone.

The publication is from 2000 (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology), a journal based in England.

More context: all human trials.