A comparative study of the acceptability and effect of goserelin and nafarelin on endometriosis

What Was Tested

This randomized controlled trial paper looks at Goserelin and Nafarelin in the context of endometriosis.

The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.

Evaluations were made every 3 months for quantification of pain, bleeding and adverse events and convenience of treatment, and at 3 months after the end of treatment, when a control laparoscopy was performed for evaluation of changes in endometriotic lesion size, color and location.

Who Took Part

The abstract describes 252 women taking part.

By PubMed's age tags, the people studied were teenagers, adults and middle-aged adults, women only.

Twenty-eight departments of obstetrics and gynecology in Sweden, Norway, Denmark and Finland were included.

How the Study Was Run

The researchers set it up as a randomized and parallel-group study.

Because people in this Goserelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Groups ran in parallel: each of the women stayed in one arm throughout.

What Was Measured

Evaluations were made every 3 months for quantification of pain, bleeding and adverse events and convenience of treatment, and at 3 months after the end of treatment, when a control laparoscopy was performed for evaluation of changes in endometriotic lesion size, color and location.

There were no correlations between location, lesion size or type of lesion, and symptom score in either group, or between treatments with regard to change in endometriosis score.

PubMed files the paper under topics including Endometriosis, Estradiol, Follicle Stimulating Hormone, Goserelin, Hormones, Luteinizing Hormone and Nafarelin.

What This Means in Plain Language

The paper is a randomized and parallel-group study of Goserelin and Nafarelin in 252 women in people with endometriosis.

The publication is from 2000 (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology), a journal based in England.

More context: the Goserelin compound page and the Nafarelin compound page, Endometriosis research.