Intraplatelet calcium levels in patients with acute renal failure before and after the administration of loop diuretics.

What Was Tested

The paper reports a study of Diuretics, published as a randomized controlled trial.

Intracellular calcium [Ca](i) has been found to be elevated in hypoxic cells in vitro and in erythrocytes and lymphocytes from patients who are septic.

The researchers report the results of a study designed to measure [Ca](i) in platelets from patients with acute renal failure (ARF) before and after the administration of loop diuretics.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

Sixteen healthy adults and seven patients with ARF were enrolled into the study.

Data from subjects given either frusemide or torasemide have been considered together and termed the diuretic group.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Diuretics group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Diuretics, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Diuretics could be set against what happens without it.

Intraplatelet calcium was measured using a fluorescent probe (quin2).

What Was Measured

The researchers report the results of a study designed to measure [Ca](i) in platelets from patients with acute renal failure (ARF) before and after the administration of loop diuretics.

Topics PubMed links to this paper include Acute Kidney Injury, Arginine Vasopressin, Blood Platelets, Calcium, Chelating Agents, Diuretics and Egtazic Acid.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Diuretics.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2001 (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association), a journal based in England.

More context: all human trials.